| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C34H34ClN7O |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
NNMT-IN-3 is a potent, selective inhibitor of nicotinamide N-methyltransferase (NNMT), with IC50 values of 1.1 nM in a cell-free assay and 0.4 μM in a cell-based assay. It can be used in the research of diseases such as obesity, type 2 diabetes, and cancer[1]. It is supplied as an off-white to light yellow solid (C34H34ClN7O, MW 592.13).
Physical & Chemical Properties
| CAS Number | 3031493-74-7 |
|---|---|
| Molecular Formula | C34H34ClN7O |
| Molecular Weight | 592.13 g/mol |
| Appearance | Solid |
| Color | Off-white to light yellow |
| SMILES | CC1=CC=C2C(C=C(N2CC3=CC=C(C=C3)Cl)[C@H]4C[C@@H](CN4C(C5=CC6=C(NC(C)=C6)N=C5)=O)N7N=C(C=C7CN)C)=C1 |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 1.1 nM (NNMT, cell-free), 0.4 μM (NNMT, cell-based)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
In cell-free assays, NNMT-IN-3 (22-24 h) potently inhibits recombinant human NNMT, with an IC50 of 0.0011 μM[1]. In NNMT-overexpressing HEK293 cells, NNMT-IN-3 inhibits NNMT activity, with an IC50 of 0.40 μM[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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