| Field | Specification |
|---|---|
| Target | |
| Alternative names | BNOS, Constitutive NOS, IHPS 1, IHPS1, N-NOS, NC-NOS, neuronal Nitric Oxide Synthase, Neuronal NOS, Nitric oxide synthase neuronal included, Nitric oxide synthase 1 (neuronal), Nitric oxide synthase 1, NNOS, NO, NOS 1, NOS, NOS type I, NOS-I, NOS1, NOS1_HUMAN |
| Gene ID | |
| Accession number | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | Partial Human Recombinant NOS1 Protein |
| Purification | |
| Cellular localization | |
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Neuronal nitric oxide synthase (NOS1 or nNOS) is a constitutive enzyme responsible for producing nitric oxide (NO), a gaseous neurotransmitter involved in synaptic plasticity, neurovascular coupling, and neuroprotection. NOS1 catalyzes the oxidation of L-arginine to L-citrulline and NO, modulating intracellular signaling cascades. In neurodegenerative diseases, dysregulated NOS1 activity contributes to oxidative stress, mitochondrial dysfunction, and excitotoxicity. Excessive NO production can lead to peroxynitrite formation and protein nitration, exacerbating neuronal injury. Targeting NOS1 and its downstream pathways offers potential for therapeutic intervention in conditions such as Alzheimer’s disease, Parkinson’s disease, and ALS.
A 1:1000 dilution of SMC-609 was sufficient for detection of NOS1/Nnos in 7.5 ug of Mouse Brain Cerebellum by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-609D — Size: 100 ug: nNOS Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-609D, RRID: AB_3716631)
- SMC-609D-A390 — Size: 100 ug: nNOS Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-609D-A390, RRID: AB_3716632)
- SMC-609D-A488 — Size: 100 ug: nNOS Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-609D-A488, RRID: AB_3716633)
- SMC-609D-A594 — Size: 100 ug: nNOS Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-609D-A594, RRID: AB_3716634)
- SMC-609D-APC — Size: 100 ug: nNOS Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-609D-APC, RRID: AB_3716635)
- SMC-609D-BI — Size: 100 ug: nNOS Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-609D-BI, RRID: AB_3716636)
- SMC-609D-FITC — Size: 100 ug: nNOS Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-609D-FITC, RRID: AB_3716637)
- SMC-609D-HRP — Size: 100 ug: nNOS Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-609D-HRP, RRID: AB_3716638)
- SMC-609D-PCP — Size: 100 ug: nNOS Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-609D-PCP, RRID: AB_3716639)
- SMC-609D-RPE — Size: 100 ug: nNOS Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-609D-RPE, RRID: AB_3716640)
- SMC-609S — Size: 12 ug: nNOS Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-609S, RRID: AB_3716631)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
