| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Methyl (5-[2-thienylcarbonyl]-1H-benzimidazol-2-yl |
| Cas No. | |
| Form | White to off-white powder. |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (10 mg/ml, warm) |
| Source | Synthetic |
| Storage |
Nocodazole is a microtubule-depolymerizing agent that disrupts cytoskeletal dynamics by inhibiting tubulin polymerization. In neuroscience, nocodazole is used to study axonal transport, neuronal morphology, and cell cycle regulation. Microtubule integrity is essential for neuronal function, and its disruption is implicated in neurodegenerative diseases such as Alzheimer's and ALS. Nocodazole helps elucidate the role of cytoskeletal organization in synaptic transmission, neurodevelopment, and neurodegeneration. Its application in cellular models provides insights into the mechanisms of neuronal injury and repair.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
- H341- Suspected of causing genetic defects.
- H361d – Suspected of damaging the unborn child
Precautionary Phrases:
P281 – Use personal protective equipment as required.
Nocodazole (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-367)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Kelian Xu., Schwarz P,. Luduena R,. (2002) Drug Drug Dev.Re. 55: 91-96.
