| Field | Specification |
|---|---|
| Target | |
| Alternative names | BRL-4664 |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C25H33NO2 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Nonabine, also known as BRL-4664, is an orally active chromenol derivative that functions as a cannabinoid-like antiemetic. It has been described as controlling nausea and vomiting induced by cancer chemotherapy regimens, and it can be used in research on lymphoma and chemotherapy-induced nausea and vomiting[1][2]. It is supplied as a white to off-white solid (C25H33NO2, MW 379.54) at 99.95% purity.
Physical & Chemical Properties
| CAS Number | 16985-03-8 |
|---|---|
| Molecular Formula | C25H33NO2 |
| Molecular Weight | 379.54 g/mol |
| Purity | 99.95% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | OC1=C2C(C3=CC=NC=C3)=CC(C)(OC2=CC(C(C(CCCCC)C)C)=C1)C |
| Target | CB1 |
| Signaling Pathway | GPCR/G Protein; Neuronal Signaling |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[2]. Gardner D V, et al. A versatile approach to analogues of the cannabinoid‐like anti‐emetic nonabine (BRL 4664)[J]. Journal of heterocyclic chemistry, 1984, 21(1): 121-127.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
