Nonivamide

Product details

• Chemical name: N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide.
• Also known as: Pelargonic acid vanillylamide/PAVA
• CAS number: 2444-46-4
• Molecular formula: C17H27NO4.
• Purity: >98%
• Concentration: 100 nM - 10 µM.
• Form: Lyophilized powder.
• Solubility: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Reconstitution: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: TRPV1 channels
• Source: Synthetic
• Activity: Nonivamide is a TRPV1 activator1.
• Alternative names: Pelargonic acid vanillylamide/PAVA

Scientific background

Nonivamide is a synthetic analog of capsaicin, a pungent ingredient in chili peppers. It binds to TRPV1 channel and activates it with high potency (EC50 ≈ 10-7 M). Treatment with nonivamide activates TRPV1 channels, allowing non-selective cation flux into neurons, causing membrane depolarization and increase in cytosolic Ca2+ due to release of Ca2+ from the endoplasmic reticulum1.TRPV1 is a member of the TRP family of ion-channels and found throughout the body in epithelial cells and in peripheral and central terminals in neurons. The TRPV family includes six mammalian ion channels, TRPV1-TRPV6. TRPV1 is a Ca2+-permeable channel which is activated and modulated by a variety of exogenous stimuli such as heat, changes in pH, and irritant and pungent compounds and by selected molecules released during inflammatory processes and tissue damage2.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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