| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Up to 25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: N-(1-adamantyl)quinoxaline-2-carboxamide.
- CAS number: 226878-01-9
- Molecular formula: C19H21N3O.
- Purity: >98%
- Concentration: 10 nM - 1 uM.
- Form: Lyophilized powder.
- Solubility: Up to 25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: mGluR1, mGluR5 receptors
- Source: Synthetic
- Activity: NPS 2390, a quinoxaline derivative, is a potent and selective non-competitive antagonist of Group I mGluRs, acting on mGluR1 and mGluR5 with IC50 values of to 5.2 and 82 nM, respectively, while having no effect on mGluR2, mGluR8 and other targets at 30 μM1-3.
Scientific background
NPS 2390, a quinoxaline derivative, is a synthetic, potent, selective and non-competitive antagonist of group I metabotropic glutamate receptors comprising mGluR1 and mGluR5 receptors with IC50 values of 5.2 and 8.2 nM respectively7. The compound shows very low affinity towards other mGluR receptors.Several studies suggest that NPS 2390 acts on a site that is different from the glutamate binding pocket. It is likely that the compound acts at the transmembrane segment VII region of the receptors1-3.Metabotropic glutamate receptors (mGluRs) are G protein coupled receptors (GPCR) that play an important role in synaptic plasticity and other neuro-physiological and pathological processes including a major role in central sensitization and neuropathic pain. Type 1 mGluRs are mainly found in somatodendritic domains and postsynaptically regulate neuronal excitability and synaptic transmission through several intracellular second messenger systems4,5. The mGlu1 receptors play an important role in motor learning and motor coordination whereas mGlu5 receptors contribute to induction of long-term potentiation and associative learning6.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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