| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C25H25N3O2S |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
NPS ALX Compound 4a is a potent, selective 5-hydroxytryptamine 6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM[1]. It is supplied as a light yellow to yellow solid with the molecular formula C25H25N3O2S and a molecular weight of 431.55 g/mol.
Physical & Chemical Properties
| CAS Number | 299433-10-6 |
|---|---|
| Molecular Formula | C25H25N3O2S |
| Molecular Weight | 431.55 g/mol |
| Appearance | Solid |
| Color | Light yellow to yellow |
| SMILES | O=S(N1C=CC2=C1C=C(N3CC(CCC4)N4CC3)C=C2)(C5=C6C=CC=CC6=CC=C5)=O |
| Target | 5-HT 6 Receptor |
| Signaling Pathway | GPCR/G Protein; Neuronal Signaling |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
5-HT6 Receptor |
5-HT6 Receptor 7.2 nM (IC50) |
5-HT6 Receptor 0.2 nM (Ki) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
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