| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 5-[(4-bromophenyl)methyl]-1,3-thiazol-2-amine.
- CAS number: 327062-46-4
- Molecular formula: C10H9BrN2S.
- Purity: >99%
- Concentration: 5 µM - 100 µM.
- Form: Lyophilized powder.
- Solubility: 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: KCa1.1 K+ channels
- Source: Synthetic
- Activity: NS19504 is a KCa1.1 channel opener1.
Scientific background
NS19504 is a potent and selective activator of the large-conductance Ca2+-activated K+ channel, BKCa (KCa1.1). It activates heterologously expressed and native BK channels in a concentration-dependent manner with an EC50 value of 11.0 ± 1.4 µM1.Several researches have indicated that NS19504 could reduce nonvoiding contractions associated with spontaneous bladder overactivity while having a minimal effect on voluntary bladder emptying.BKCa channels are important regulators of urinary bladder function and may be used as an attractive therapeutic target in bladder disorders1.The large conductance Ca2+-activated K+ channels play a role in controlling the cell volume, they affect the driving force for Ca2+ influx and thus exert a secondary control on cell migration through regulation of Ca2+ signals by modulating the membrane potential2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
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