| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | NSC-63284, 6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione |
| Cas No. | |
| Form | Red solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 50 mM in DMSO and to 50 mM in ethanol |
| Source | Synthetic |
| Storage |
NSC 663284 is a potent, cell-permeable, and irreversible inhibitor of the CDC25 phosphatase family, including CDC25A, CDC25B, and CDC25C. While primarily studied in oncology for its role in cell cycle regulation and tumor suppression, its mechanism of action—targeting cell cycle checkpoints—has implications in neurodegenerative disease research. Aberrant cell cycle re-entry is a hallmark of neuronal death in disorders such as Alzheimer's disease, making CDC25 inhibition a potential neuroprotective strategy.
Classification: Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H315 Causes skin irritation.
- H319 Causes serious eye irritation.
- H335 May cause respiratory irritation.
Precautionary statements:
- P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
- P264 Wash skin thoroughly after handling.
- P271 Use only outdoors or in a well-ventilated area.
- P280 Wear protective gloves/ eye protection/ face protection.
- P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
- P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
- P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
- P321 Specific treatment (see supplemental first aid instructions on this label).
- P332 + P313 If skin irritation occurs: Get medical advice/ attention.
- P337 + P313 If eye irritation persists: Get medical advice/ attention.
- P362 Take off contaminated clothing and wash before reuse.
- P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
- P405 Store locked up.
- P501 Dispose of contents/ container to an approved waste disposal plant
NSC 663284 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-520)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Brisson M., et al. (2005) Mol. Pharm. 68(6): 1810–1820.
