| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C10H5Cl2N3O3S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
NTZ-24 is a selective inhibitor of the STAT3 pathway. It suppresses STAT3 phosphorylation at Tyr705, blocks the STAT3-DNA interaction, and downregulates STAT3 downstream target proteins, while also inducing cell-cycle arrest and promoting apoptosis in cancer cells. Against HeLa cells it exerts significant antiproliferative activity (IC50 = 3.3 μM), and can be used in cervical cancer research[1]. It has a molecular formula of C10H5Cl2N3O3S and a molecular weight of 318.14 g/mol.
Physical & Chemical Properties
| CAS Number | 69819-42-7 |
|---|---|
| Molecular Formula | C10H5Cl2N3O3S |
| Molecular Weight | 318.14 g/mol |
| SMILES | O=C(C1=CC=C(C(Cl)=C1)Cl)NC2=NC=C([N+]([O-])=O)S2 |
| Target | STAT3, IL-6 |
| Signaling Pathway | JAK/STAT Signaling; Stem Cell/Wnt; Immunology/Inflammation; Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
STAT3 0.8 μM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In HEK-Blue IL-6 cells, NTZ-24 inhibits the IL-6/JAK/STAT3 pathway with an IC50 of 0.8 μM[1]. NTZ-24 (48 h) suppresses the proliferation of HeLa epithelial carcinoma cells, with an IC50 of 3.3 μM[1]. In human normal embryonic kidney HEK 293T cells, NTZ-24 (10-50 μM; 48 h) shows low cytotoxicity, with cell viability inhibition of 8.0% at 10 μM and 19.1% at 50 μM[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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