| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C40H56ClN7O13 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
NVOC cage-TMP-Halo is a cell-permeable, photoactivatable inducer of protein dimerization that can rapidly and reversibly control protein localization in living cells, making it useful for research into dynamic cellular processes[1]. It is supplied as an off-white to light yellow solid (C40H56ClN7O13, MW 878.36) at 96.03% purity.
Physical & Chemical Properties
| CAS Number | 2137894-98-3 |
|---|---|
| Molecular Formula | C40H56ClN7O13 |
| Molecular Weight | 878.36 g/mol |
| Purity | 96.03% |
| Appearance | Solid |
| Color | Off-white to light yellow |
| SMILES | COC1=C(OC)C=C(COC(NC2=NC(N)=C(CC3=CC(OC)=C(OCCCNC(CCC(NCCOCCOCCCCCCCl)=O)=O)C(OC)=C3)C=N2)=O)C([N+]([O-])=O)=C1 |
| Solubility | In Vitro: DMSO: 150 mg/mL (170.77 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 150 mg/mL (170.77 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
NVOC cage-TMP-Halo (20 μM, 60 min) showed dramatic recruitment of mCherry-eDHFR to centromeres, with a t1/2 of ~ 15 s, in a HeLa cell line expressing CENPB-GFP-Haloenzyme and mCherry-eDHFR[1]. NVOC cage-TMP-Halo (20 μM, 15, 30, and 60 min) is capable of spatially precise control of protein localization in the HeLa cell line[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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