| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C100H176N4O10 |
| Purity | |
| SMILES | |
| Form | Liquid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
OF-C4-Deg-Lin is an ionizable lipid available with varied linker lengths. It can be used to generate lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA[1]. It is supplied as a light yellow to yellow liquid (C100H176N4O10, MW 1594.49) at 98.0% purity.
Physical & Chemical Properties
| CAS Number | 2383003-60-7 |
|---|---|
| Molecular Formula | C100H176N4O10 |
| Molecular Weight | 1594.49 g/mol |
| Purity | 98.0% |
| Appearance | Liquid |
| Color | Light yellow to yellow |
| Density | 0.959 g/cm3 |
| SMILES | CCCCC/C=C\C/C=C\CCCCCCCC(OCCCCN(CCCCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)CCCC[C@H]1C(N[C@H](C(N1)=O)CCCCN(CCCCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O)=O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Solubility | In Vitro: DMSO: 100 mg/mL (62.72 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Ethanol: ≥ 50 mg/mL (31.36 mM) * "≥" means soluble, but saturation unknown. |
| Storage | Pure form: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (62.72 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
| Ethanol | ≥ 50 mg/mL (31.36 mM) | — |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% saline |
|---|---|
| Result | ≥ 2.5 mg/mL (1.57 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 400 μL PEG300; then 50 μL Tween-80; then 450 μL saline to bring the volume to 1 mL. Saline: dissolve 0.9 g sodium chloride in ddH2O and make up to 100 mL. |
Data provided by the manufacturer.
In Vivo
In the spleen, most protein expression is induced by OF-C4-Deg-Lin LNPs entrapping mRNA coding for luciferase; translation in the liver is minimal, and in other organs it is negligible[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Interactions between mRNA lipid nanoparticles and immune cells in fresh human whole blood. Eur J Pharm Biopharm 2026 Jun 9:115146. PMID: 42264006
