| Field | Specification |
|---|---|
| Alternative names | 3,4-DHPEA-EA |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C19H22O8 |
| Purity | |
| SMILES | |
| Form | Oil |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Oleuropein Aglycone, also known as 3,4-DHPEA-EA, is a polyphenol formed as the aglycone of oleuropein through enzymatic, acidic, or acetylated hydrolysis. Dietary intake at 50 mg/kg increases neuronal autophagic vesicle numbers, reverses the cognitive deficits seen in TgCRND8 transgenic mice modeling Alzheimer's disease, and lowers histone deacetylase 2 (HDAC2) levels in the cortex and hippocampus. In a rat model of high-fat diet-induced obesity, it raises UCP1 protein levels, interscapular brown adipose tissue epinephrine, and urinary norepinephrine, while lowering plasma leptin and total abdominal adipose tissue weight. It further lessens lipid peroxidation, IL-1β levels, and neutrophil infiltration in the lungs of mice with carrageenan-induced pleurisy. It is supplied as an off-white to light yellow oil (C19H22O8, MW 378.37) at 98.46% purity.
Physical & Chemical Properties
| CAS Number | 31773-95-2 |
|---|---|
| Molecular Formula | C19H22O8 |
| Molecular Weight | 378.37 g/mol |
| Purity | 98.46% |
| Appearance | Oil |
| Color | Off-white to light yellow |
| SMILES | O=C(OCCC1=CC=C(O)C(O)=C1)C[C@H]2/C([C@H](O)OC=C2C(OC)=O)=C\C |
| Signaling Pathway | Neuronal Signaling; GPCR/G Protein; Epigenetics; Cell Cycle/DNA Damage |
| Solubility | In Vitro: DMSO: 50 mg/mL (132.15 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Xu, et al. Structure properties, acquisition protocols, and biological activities of oleuropein aglycone. Front. Chem. 6, 239 (2018).
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 50 mg/mL (132.15 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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Nutraceuticals. 2026 Jun;6(2):24.
