| Field | Specification |
|---|---|
| Alternative names | SMTP-7 |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C51H68N2O10 |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Orniplabin, also known as SMTP-7, is a plasminogen modulator with a human EC50 of 65 μM. It enhances activation of plasminogen by plasminogen activators, increases fibrin-binding of plasminogen, and elevates plasma levels of the plasmin-α2-antiplasmin complex in vivo, and it can be used in research on pulmonary embolism and thrombotic stroke[1]. It is supplied as a white to off-white solid (C51H68N2O10, MW 869.09).
Physical & Chemical Properties
| CAS Number | 733805-92-0 |
|---|---|
| Molecular Formula | C51H68N2O10 |
| Molecular Weight | 869.09 g/mol |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C1C2=C(C3=C(C[C@H](O)[C@@](CC/C=C(C)/CC/C=C(C)/C)(C)O3)C(O)=C2)CN1[C@H](C(O)=O)CCCN4CC5=C(C=C(O)C6=C5O[C@](CC/C=C(C)/CC/C=C(C)/C)(C)[C@@H](O)C6)C4=O |
| Signaling Pathway | Immunology/Inflammation; NF-κB; Metabolic Enzyme/Protease |
| Storage | -20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
Orniplabin (65-100 μM) strongly enhances u-PA-catalyzed activation of purified human plasminogen, with an EC10 of 65 μM and a maximal 102-fold enhancement, and increases catalytic turnover by modifying plasminogen[1]. Orniplabin (100 μM; 30 min) promotes u-PA-catalyzed conversion of purified human plasminogen into active two-chain plasmin[1]. In purified human plasminogen, Orniplabin (120 μM) induces a conformational change, as indicated by a shorter elution time in size-exclusion chromatography[1].
In Vivo
In healthy male ICR mice, Orniplabin (SMTP-7) (5-10 mg/kg; i.v.; bolus injection) enhances in vivo plasmin generation, raising plasma Pm-AP levels ~1.5-fold[1]. In a rat pulmonary embolism model, Orniplabin (5 mg/kg; i.v.; bolus injection; administered ~20 minutes post-embolization) improves thrombus clearance ~3-fold, and clearance rises further when combined with scu-PA[1]. In healthy male ICR mice, Orniplabin (5-30 mg/kg; i.v.; bolus injection) does not raise bleeding risk[1].
| Animal Model | ICR (male, 7 weeks of age)[1] |
|---|---|
| Dosage | 5 mg/kg; 10 mg/kg |
| Administration | i.v.; bolus injection |
| Result | Elevated plasma Pm-AP levels ~1.5-fold relative to saline-treated controls. |
| Animal Model | Wistar (male, ~120 g)[1] |
|---|---|
| Dosage | 5 mg/kg (alone); 5 mg/kg (with scu-PA) |
| Administration | i.v.; bolus injection; administered ~20 minutes post-embolization |
| Result | Increased the clot clearance rate to 19.8% per 20 minutes, a ~3-fold increase relative to the spontaneous clearance rate of 6.4% per 20 minutes observed in saline-treated controls. Increased the clot clearance rate to 42.3% per 20 minutes when combined with scu-PA. |
| Animal Model | ICR (male, 6 weeks of age)[1] |
|---|---|
| Dosage | 5 mg/kg; 30 mg/kg |
| Administration | i.v.; bolus injection |
| Result | Did not cause a statistically significant prolongation of bleeding time relative to controls. Did not cause a statistically significant increase in bleeding volume relative to controls. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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