| Field | Specification |
|---|---|
| Alternative names | 6-Carboxyuracil potassium; Vitamin B13 potassium |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C5H3KN2O4 |
| Purity | |
| Activity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Orotic acid potassium, also known as 6-Carboxyuracil potassium or Vitamin B13 potassium, is a precursor of pyrimidine bases involved in the synthesis of DNA and RNA. It stimulates the growth of animals, plants, and microorganisms, participates in carbohydrate metabolism, and is necessary for the growth and life activities of organisms. It also serves as a measurement indicator in routine newborn screening for urea cycle abnormalities and can cause hepatic steatosis and hepatomegaly in rats[1][2][3][4]. It is supplied as a white to off-white solid (C5H3KN2O4, MW 194.19) at 99.51% purity.
Physical & Chemical Properties
| CAS Number | 24598-73-0 |
|---|---|
| Molecular Formula | C5H3KN2O4 |
| Molecular Weight | 194.19 g/mol |
| Purity | 99.51% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C(C(NC1=O)=CC(N1)=O)O[K] |
| Signaling Pathway | Metabolic Enzyme/Protease; Cell Cycle/DNA Damage |
| Bioactivity Class | Human Endogenous Metabolite |
| Solubility | In Vitro: H2O: 2 mg/mL (10.30 mM; Requires sonication and warming and heat to 60°C) |
| Storage | 4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[4]. Kochkin, et al. "Orotic acid and its derivatives. Preparation, properties, and uses." Pharmaceutical Chemistry Journal 11.8 (1977): 1155-1160.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 2 mg/mL (10.30 mM) | requires sonication and warming and heat to 60°C |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
If water is used as the stock solvent, dilute to the working solution and sterilize it through a 0.22 μm filter before use.
Data provided by the manufacturer.
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Lithocholic acid phenocopies anti-ageing effects of calorie restriction. Nature 2025 Jul;643(8070):192-200. PMID: 39695227
Pestiviruses utilize pyrimidine metabolism to regulate mitophagy for viral replication. Autophagy 2026 Jul;22(7):1657-1678. PMID: 41968644
Antimycin A inhibits alpha-herpesvirus replication by disrupting the formation of pyrimidinosomes. J Adv Res 2025 May 10:S2090-1232(25)00309-1. PMID: 40354935
Combination of PARP inhibitor and temozolomide to suppress chordoma progression. J Mol Med (Berl) 2019 Aug;97(8):1183-1193.
