| Field | Specification |
|---|---|
| Alternative names | Ostruthine |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C19H22O3 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Ostruthin, also known as ostruthine, is a natural coumarin with antibacterial and antimycobacterial activity that inhibits the growth of mycobacteria and Staphylococcus aureus. It also suppresses proliferation of vascular smooth muscle cells and de novo cellular DNA synthesis, and has been applied in research on mycobacterial infections and cardiovascular and cerebrovascular disease[1][2][3]. It is supplied as a white to off-white solid (C19H22O3, MW 298.38) at 98.84% purity.
Physical & Chemical Properties
| CAS Number | 148-83-4 |
|---|---|
| Molecular Formula | C19H22O3 |
| Molecular Weight | 298.38 g/mol |
| Purity | 98.84% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | C/C(C)=C\CC/C(C)=C/CC1=C(O)C=C2C(C=CC(O2)=O)=C1 |
| Signaling Pathway | Anti-infection; Cell Cycle/DNA Damage |
| Storage | 4°C, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[2]. V. DADÁK, et al. Neutralization of the Antibacterial Effect of Natural Coumarin Ostruthine by Vitamins K. Nature volume 205, pages709–710 (1965).
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
Ostruthin (72-120 h) potently inhibits proliferation of various rapidly growing mycobacterial strains in vitro, with minimum inhibitory concentrations (MICs) of 3.4 to 107.4 μM against Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis[1]. Ostruthine (1×10-4-1×10-3 M) potently inhibits growth and cellular oxygen consumption of Staphylococcus aureus strain BS 270[2]. In rat aortic vascular smooth muscle cells, Ostruthin (30 μM; 48 h) potently inhibits proliferation induced by 10% serum, with an IC50 of 11 μM[3]. In rat aortic vascular smooth muscle cells, Ostruthin (1-30 μM; 20 h) concentration-dependently inhibits 10% serum-induced de novo DNA synthesis, with an IC50 of 17 μM[3].
Cell Proliferation Assay[3]
| Cell Line | rat aortic vascular smooth muscle cells (VSMC) |
|---|---|
| Concentration | 30 μM |
| Incubation Time | 48 h (with 30 min pretreatment) |
| Result | Inhibited serum-induced VSMC proliferation with an IC50 of 11 μM. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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