| Field | Specification |
|---|---|
| Applications | |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Oxythiamine diphosphate ammonium is a potent inhibitor of transketolase (TK)[1]. It is supplied as a white to light yellow solid at 98.42% purity.
Physical & Chemical Properties
| Purity | 98.42% |
|---|---|
| Appearance | Solid |
| Color | White to light yellow |
| SMILES | CC1=C(CCOP(OP(O)(O)=O)([O-])=O)SC=[N+]1CC2=CN=C(C)NC2=O.N.[x] |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Solubility | In Vitro: H2O: 12.5 mg/mL (Requires sonication) |
| Storage | -20°C, protect from light, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 12.5 mg/mL | requires sonication |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light, stored under nitrogen; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
Oxythiamine diphosphate ammonium inhibits rat liver TK by 50% at concentrations of 0.02-0.2 μM. For yeast transketolase, the I50 value of Oxythiamine diphosphate ammonium is approximately 0.03 μM[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Pharmacological perturbation of thiamine metabolism sensitizes Pseudomonas aeruginosa to multiple antibacterial agents. Cell Chem Biol 2022 Aug 18;29(8):1317-1324.e5. PMID: 35901793
