| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C12H17N3O8P2S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Oxythiamine diphosphate is a potent inhibitor of transketolase (TK)[1]. It has the molecular formula C12H17N3O8P2S (MW 425.29).
Physical & Chemical Properties
| CAS Number | 10497-04-8 |
|---|---|
| Molecular Formula | C12H17N3O8P2S |
| Molecular Weight | 425.29 g/mol |
| SMILES | CC1=C(CCOP(OP(O)(O)=O)([O-])=O)SC=[N+]1CC2=CN=C(C)NC2=O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
Activity & Target
Ki: 30 nM (thiamine pyrophosphate)[1].
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Oxythiamine diphosphate inhibits rat liver TK by 50% at concentrations of 0.02–0.2 μM. For yeast transketolase, the I50 value of Oxythiamine diphosphate is approximately 0.03 μM[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Pharmacological perturbation of thiamine metabolism sensitizes Pseudomonas aeruginosa to multiple antibacterial agents. Cell Chem Biol 2022 Aug 18;29(8):1317-1324.e5. PMID: 35901793
