| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C25H33Cl2N |
| SMILES | |
| Form | Oil |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
OY-201 is a candidate anti-ischemic stroke agent capable of crossing the blood-brain barrier. It has demonstrated good safety and neuroprotective activity in both in vitro and in vivo models[1]. It is supplied as an oil (C25H33Cl2N, MW 418.44).
Physical & Chemical Properties
| CAS Number | 2962943-05-9 |
|---|---|
| Molecular Formula | C25H33Cl2N |
| Molecular Weight | 418.44 g/mol |
| Appearance | Oil |
| SMILES | CCCCCCCCN([C@H]1CC[C@H](C2=CC=CC=C21)C3=CC=C(C(Cl)=C3)Cl)C |
| Signaling Pathway | Neurological Disease |
| Solubility | In Vitro: DMSO: 25 mg/mL (59.75 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 25 mg/mL (59.75 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Data provided by the manufacturer.
In Vivo
In MCAO mice, OY-201 (10-20 mg/kg, IP) attenuates brain injury and shows superior safety relative to sertraline[1].
| Animal Model | Male C57BL/6J mice (Middle cerebral artery occlusion (MACO)-induced brain infarction model)[1] |
|---|---|
| Dosage | 10 mg/kg and 20 mg/kg |
| Administration | IP |
| Result | Attenuated brain injury of MCAO mice. 10 mg/kg of compound OY-201 reduced the infarcted volume to 13.3% and decreased the neurological severity scores to 1.5. Moreover, treatment with a higher dose of compound OY-201 (20 mg/kg) did not further improve the results, which showed an almost equivalent protective effect. OY-201 at 20 mg/kg significantly ameliorated the mortality of MCAO mice (35.7%) and the survival rate of compound OY-201 was 100% at the dose of 10 mg/kg. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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