| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Source | Endogenous metabolite — Human Gut Microbiota Metabolites; Plant; Animal; Microbial — Widespread |
| Molecular weight | |
| Molecular formula | C16H32O2.1/2Ca |
| Activity | |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Palmitic acid calcium is a long-chain saturated fatty acid found in both animals and plants. It can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, and it is used to establish a cell steatosis model[1][2]. It has the formula C16H32O2.1/2Ca and a molecular weight of 275.46 g/mol.
Physical & Chemical Properties
| CAS Number | 542-42-7 |
|---|---|
| Molecular Formula | C16H32O2.1/2Ca |
| Molecular Weight | 275.46 g/mol |
| Structure Classification | Ketones, Aldehydes, Acids |
| SMILES | CCCCCCCCCCCCCCCC([O-])=O.[Ca+2].[0.5] |
| Target | Grp78 |
| Signaling Pathway | Cell Cycle/DNA Damage; Metabolic Enzyme/Protease |
| Bioactivity Class | Human Endogenous Metabolite |
| Initial Source | Endogenous metabolite — Human Gut Microbiota Metabolites; Plant; Animal; Microbial — Widespread |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In LX2, Huh7 and MIHA hepatic cell lines, Palmitic acid calcium (0.1, 0.25 or 0.5 mM; 12-72 h) raises the mRNA levels of Notch1, 2 and 4[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulin. Signal Transduct Target Ther 2025 Dec 3;10(1):394. PMID: 41330906
Lithocholic acid phenocopies anti-ageing effects of calorie restriction. Nature 2025 Jul;643(8070):192-200. PMID: 39695227
Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling. Science 2025 Mar 14;387(6739):eadm9805. PMID: 40080571
Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus. Bioact Mater 2023 Nov 9:33:85-99. PMID: 38024229
Lipid accumulation in tuberculosis granulomas inhibits macrophage-CD4+ T cell interactions and infection control. Nat Microbiol 2026 Jun;11(6):1677-1695. PMID: 41933199
RETREG1-mediated reticulophagy is activated by an ATF4-CEBPG/C/EBPγ heterodimer and confers protection against lipotoxicity. Autophagy 2025 Dec;21(12):2614-2632. PMID: 40437698
TRIM21-mediated ubiquitination of SQSTM1/p62 abolishes its Ser403 phosphorylation and enhances palmitic acid cytotoxicity. Autophagy 2025 Jan;21(1):178-190. PMID: 39172027
Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression. Cell Discov 2023 Mar 7;9(1):26. PMID: 36878899
Acacetin ameliorates MASLD by inhibiting the Notch1 pathway in hepatocytes and reprogramming macrophage polarization via Keap1-Nrf2-mediated restraint of ferroptosis. Metabolism 2026 Jun 7:182:156670. PMID: 42259496
Niraparib restricts intraperitoneal metastases of ovarian cancer by eliciting CD36-dependent ferroptosis. Redox Biol 2025 Mar:80:103528. PMID: 39922130
