| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C34H34F2N4O3 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
pan-KRAS-IN-2 is a pan-inhibitor with IC50 values ≤10 nM against KRAS WT and the mutants G12D, G12C, G12V, G12S, G12A and Q61H, and an IC50 >10 μM against KRAS G13D. It can be used to study various KRAS-mediated cancers, such as pancreatic and colorectal cancer[1]. It is supplied as a white to off-white solid (C34H34F2N4O3, MW 584.66) at 98.01% purity.
Physical & Chemical Properties
| CAS Number | 2882825-14-9 |
|---|---|
| Molecular Formula | C34H34F2N4O3 |
| Molecular Weight | 584.66 g/mol |
| Purity | 98.01% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CC1=C(C2=CC(O)=CC3=C2C(C#C)=C(F)C=C3)C=CC4=C1N=C(N=C4N5CCCOCC5)OC[C@@]67N(CCC7)C[C@@H](C6)F |
| Target | K-Ras WT, KRas G12D, KRas G12C, KRas G12V, KRas G12S, KRas Q61H, KRAS G13D |
| Signaling Pathway | GPCR/G Protein; MAPK/ERK Pathway |
| Solubility | In Vitro: DMSO: 125 mg/mL (213.80 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
K-Ras WT ≤ 10 nM (IC50) |
KRas G12D ≤ 10 nM (IC50) |
KRas G12C ≤ 10 nM (IC50) |
KRas G12V ≤ 10 nM (IC50) |
KRas G12S ≤ 10 nM (IC50) |
KRas Q61H ≤ 10 nM (IC50) |
KRAS G13D > 10 μM (IC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Jones C, et al. Quinazoline derivatives useful as Ras inhibitors and their preparation. World Intellectual Property Organization, WO2022258974 A1. 2022-12-15.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 125 mg/mL (213.80 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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