| Field | Specification |
|---|---|
| Alternative names | T3761 |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C16H15FN2O4 |
| Activity | |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Pazufloxacin, also known as T3761, is an orally active fluoroquinolone antimicrobial agent that inhibits DNA gyrase, with IC50 values of 0.88 μg/mL against E. coli and 1.9 μg/mL against P. aeruginosa. Its broad-spectrum activity spans Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria, with MIC90 values ranging from 0.025 to 100 μg/mL. It is studied for systemic infections, lung infections, urinary tract infections, and Legionella pneumonia[1][2][3][4][5]. It has the molecular formula C16H15FN2O4 and a molecular weight of 318.30 g/mol.
Physical & Chemical Properties
| CAS Number | 127045-41-4 |
|---|---|
| Molecular Formula | C16H15FN2O4 |
| Molecular Weight | 318.30 g/mol |
| SMILES | O=C(C(C1=O)=CN2[C@@H](C)COC3=C(C4(N)CC4)C(F)=CC1=C23)O |
| Signaling Pathway | Anti-infection; Cell Cycle/DNA Damage |
| Bioactivity Class | Quinolone |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Broad-spectrum antibacterial activity is exhibited by Pazufloxacin against gram-positive bacteria, gram-negative bacteria, and non-fermenters as well as Legionella spp. and anaerobes, with MIC90s ranging from 0.025 to 100 μg/mL[1]. DNA gyrase is inhibited by Pazufloxacin, with IC50s of 0.88 μg/mL for E. coli and 1.9 μg/mL for P. aeruginosa[2].
In Vivo
In mice with pulmonary infections, Pazufloxacin (25 mg/kg; p.o.) shows good efficacy, achieving 94% survival and eradication rates against Pseudomonas aeruginosa that exceed those of Ofloxacin and Norfloxacin[1]. In A/J mice with Legionella pneumonia, Pazufloxacin (5 mg/kg/day; i.p.; twice a day; 7 days) combined with Sivelestat lowers bacterial counts and inflammatory cells during the early phase, but does not significantly improve survival compared with monotherapy[5].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. Int J Biol Macromol 2026 Mar:352:151224. PMID: 41791543
