| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C22H18N4O3S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
PD-1/PD-L1-IN 5 is a PD-1/PD-L1 protein-protein interaction inhibitor derived from compound Example 1 of patent WO2017222976A1, with an IC50 of ≤100 nM[1]. It has the molecular formula C22H18N4O3S and a molecular weight of 418.47 g/mol.
Physical & Chemical Properties
| CAS Number | 2170209-51-3 |
|---|---|
| Molecular Formula | C22H18N4O3S |
| Molecular Weight | 418.47 g/mol |
| SMILES | O=C(C(S1)=NC2=C1CNCC2)NC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C#N |
| Signaling Pathway | Immunology/Inflammation |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: ≤100 nM (PD-1/PD-L1)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Kaijiong Xiao, et al. Heterocyclic compounds as immunomodulators. WO2017222976A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
These compounds modulate the PD-1/PD-L1 protein/protein interaction and are useful for treating various diseases, including infectious diseases and cancer. They can serve as immunomodulators[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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