| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | PD 0325901, PD-325901, N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| Cas No. | |
| Form | Off-white solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 25 mM in DMSO |
| Source | Synthetic |
| Storage |
PD325901 is a highly selective MEK1/2 inhibitor that suppresses ERK1/2 phosphorylation and downstream signaling. In neuroscience, the MEK/ERK pathway is implicated in synaptic plasticity, memory formation, and neuroinflammation. PD325901 has shown promise in preclinical models of neurodevelopmental and neurodegenerative disorders, including fragile X syndrome and Alzheimer's disease, by modulating aberrant signaling and improving cognitive outcomes.
Classification: Acute toxicity, Oral (Category 3), H301
Specific target organ toxicity -repeated exposure (Category 2), H373
Acute aquatic toxicity (Category 1), H400
Chronic aquatic toxicity (Category 1), H410
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H301 Toxic if swallowed.
- H373 May cause damage to organs through prolonged or repeated exposure.
- H410 Very toxic to aquatic life with long lasting effects.
Precautionary statements:
- P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
- P264 Wash skin thoroughly after handling.
- P270 Do not eat, drink or smoke when using this product.
- P273 Avoid release to the environment.
- P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
- P314 Get medical advice/ attention if you feel unwell.
- P321 Specific treatment (see supplemental first aid instructions on this label).
- P330 Rinse mouth.
- P391 Collect spillage.
- P405 Store locked up.
- P501 Dispose of contents/ container to an approved waste disposal plant.
PD325901 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-507)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Ciuffreda L., et al. (2009) Neoplasia. 11(8): 720–731.
