| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C15H9ClN2O2S3 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
PDK1-IN-RS2 is a mimic of the peptide docking motif (PIFtide) and a substrate-selective PDK1 inhibitor with a Kd of 9 μM. It suppresses the activation of the downstream kinase S6K1 by PDK1[1]. It is supplied as a white to light yellow solid (C15H9ClN2O2S3, MW 380.89) at 98.49% purity.
Physical & Chemical Properties
| CAS Number | 1643958-89-7 |
|---|---|
| Molecular Formula | C15H9ClN2O2S3 |
| Molecular Weight | 380.89 g/mol |
| Purity | 98.49% |
| Appearance | Solid |
| Color | White to light yellow |
| SMILES | O=S(C1=CC2=CC=CC=C2S1)(NC3=NC4=CC=C(C=C4S3)Cl)=O |
| Signaling Pathway | PI3K/Akt/mTOR |
| Solubility | In Vitro: DMSO: 125 mg/mL (328.18 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
Activity & Target
Kd: 9 μM (PDK1)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 125 mg/mL (328.18 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
Toward a peptide substrate, the catalytic activity of PDK1 is stimulated sixfold by PDK1-IN-RS2. A salt bridge links the sulfonyl group of PDK1-IN-RS2 to Arg131, since the sulfonamide is likely ionized under the crystallization conditions[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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