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Scientific Background
CD133, also known as Prominin-1 and AC133 antigen, is a 120 kD pentaspan glycoprotein with 5 transmembrane domains. CD133 was initially described as a surface antigen specific for human hematopoietic stem cells and as a marker for murine neuroepithelial cells and some embryonic epithelia. Later on, CD133 was found on other stem cells, including endothelial progenitor cells, glioblastomas, neuronal, and glial stem cells. In addition to stem cells for normal tissue, CD133 was found on cancer cells, such as some leukemia cells and brain tumor cells. Although the biological function of CD133 is not completely understood, CD133 has been extensively used as a stem cell marker for normal and cancerous tissues.
Product Overview
This monoclonal antibody (clone W6B3C1), raised in Mouse, recognizes CD133. It is validated for Flow Cytometry.
Validated Applications
| Applications | Flow Cytometry |
|---|
Optimal dilutions should be determined by the end user for each application and sample type.
Immunogen
See specifications table.
Specifications
| Host | Mouse |
|---|---|
| Clonality | Monoclonal |
| Clone | W6B3C1 |
| Isotype | Mouse IgG1, κ |
| Conjugate | PE |
| Species Reactivity | Human |
| Concentration | 5 μL/Test |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| UniProt # | O43490 |
| Gene ID | 8842 |
| Control Catalog Number | E-AB-F09792D |
| Lead Time | 2-3 business days |
| Validity | 12 months |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice packs |
| Target Synonyms | Prominin-1;AC133;Antigen AC133;CD133;CORD;CORD12;Hematopoietic stem cell antigen;MCDR;MCDR2;MSTP;MSTP061;OTTHUMP00000217744;OTTHUMP00000217745;PROM;PROM1;PROML;PROML1;Prominin-1;RP41;STGD;STGD4;hProminin |
Reactivity Notes
Validated reactivity: Human. For other species, epitope conservation may allow cross-reactivity; confirm with appropriate controls.
Safety & Handling
This product is for research use only (RUO) and is not intended for diagnostic or therapeutic use. The formulation contains sodium azide; handle with standard laboratory precautions.
Related Products
Explore related antibodies and reagents for CD133 research from Elabscience Biotechnology Co Ltd, or contact us for alternative formats.
Customization & Add-ons: Can't find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
