| Field | Specification |
|---|---|
| Alternative names | EYE001; NX1838 |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Purity | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Pegaptanib sodium, also known as EYE001 or NX1838, is an RNA aptamer with polyethylene glycol modifications that is directed against vascular endothelial growth factor (VEGF)-165. It has been used to study neovascular age-related macular degeneration (AMD)[1]. It is supplied as a white to off-white solid (MW approximately 50000) at 90.51% purity.
Physical & Chemical Properties
| CAS Number | 222716-86-1 |
|---|---|
| Molecular Weight | 50000 (Approximately) g/mol |
| Purity | 90.51% |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2?-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'?3')-dT), 5'-ester with ?,?'-[4,12-dioxo-6-[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[?-methoxypoly(oxy-1,2-ethanediyl)], sodium salt |
| Signaling Pathway | Protein Tyrosine Kinase/RTK |
| Solubility | In Vitro: H2O: 10 mg/mL (Requires sonication) |
| Storage | -20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 10 mg/mL | requires sonication |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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