| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Pemetrexed Disodium Hydrate |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Pemetrexed disodium hemipenta hydrate (CAS 357166-30-4) is a research-grade small molecule supplied by TargetMol.
Alternative names: Pemetrexed Disodium Hydrate
Physical Properties
| CAS Number | 357166-30-4 |
|---|---|
| Molecular Formula | C20H21N5O6·2Na·5/2H2O |
| Molecular Weight | 518.43 g/mol |
| SMILES | OC(CC(CH)(C(O)=O)NC(C(C=C1)=CC=C1CCC2=CNC(NC(N)=N3)=C2C3=O)=O)=O.OC(CC… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Pemetrexed disodium hemipenta hydrate (LY-231514 Disodium Hydrate) is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is 1.3 nM, 7.2 nM and 65 nM, respectively.
Target(s): Antifolate, Autophagy, Apoptosis, DHFR, DNA/RNA Synthesis
Signaling pathway(s): Apoptosis, Autophagy, Metabolism, DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
PEG300 has moderate viscosity, which facilitates the dissolution and administration of drugs, while also providing good tolerability without adverse effects on animals. PEG400 can replace PEG300. PEG600 is not very recommended because its melting point is close to room temperature.
Solid-form products can be stored at -20°C for more than 3 years. Stock solutions are typically stored at -80°C and can be stored for more than 1 year. It is recommended to aliquot the product to avoid repeated freeze-thaw cycles. For short-term storage, samples can be kept at 4°C for more than one week.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
