| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C60H80N14O14 |
| Purity | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Pentixafor is a cyclic pentapeptide ligand that targets CXCR4. It comprises the cyclic pentapeptide cyclo(dTyr-dOrn(NMe)-R-Nal-G), a linker, and a DOTA chelator, and can be labeled with 68Gallium (68Ga) for positron emission tomography (PET) imaging[1][2][3][4]. It can be used for the synthesis and research of Radionuclide-Drug Conjugates (RDCs). It is supplied as a white to off-white solid (C60H80N14O14, MW 1221.36) at 99.60% purity.
Physical & Chemical Properties
| CAS Number | 1341207-62-2 |
|---|---|
| Molecular Formula | C60H80N14O14 |
| Molecular Weight | 1221.36 g/mol |
| Purity | 99.60% |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | Cyclo{Arg-{2-Naph-Ala}-Gly-dTyr-dOrn(NMe)}-PAMBA-DOTA |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related; Immunology/Inflammation; GPCR/G Protein |
| Solubility | In Vitro: Methanol: ≥ 125 mg/mL (102.34 mM) DMSO: 100 mg/mL (81.88 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) * "≥" means soluble, but saturation unknown. |
| Storage | Sealed storage, away from moisture and light. Powder: -80°C, 2 years; -20°C, 1 year. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| Methanol | ≥ 125 mg/mL (102.34 mM) | — |
| DMSO | 100 mg/mL (81.88 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture and light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
In CXCR4-transfected Chem-1 cells, [18F]AlF-NOTA-Pentixather (195 pmol, 60 minutes) shows significant internalization and high cellular uptake[4].
In Vivo
In the PC-3 prostate cancer xenograft model, [68Ga]Pentixafor (15 MBq, single intravenous dose) is suitable for PET imaging[2]. In the Daudi lymphoma xenograft SCID mouse model, [18F]AlF-NOTA-Pentixather (0.30 MBq, single intravenous dose) can specifically target the CXCR4 receptor for PET imaging[4].
| Animal Model | PC-3 prostate cancer xenograft (nude mouse) model[2] |
|---|---|
| Dosage | 15 MBq (Pentixafor labeled with 68Gallium (68Ga), [68Ga]Pentixafor) |
| Administration | Intravenous injection (i.v., injection via tail vein), single dose |
| Result | Resulted in moderate contrast in PET imaging performed in the PC-3 tumor model. |
| Animal Model | Daudi lymphoma xenograft (SCID mouse) model[4] |
|---|---|
| Dosage | 0.30 MBq ([18F]AlF-NOTA-Pentixather, approx. 195 pmol/0.251 μg) |
| Administration | Intravenous injection (i.v.), single dose, imaging performed at 60 minutes post-injection |
| Result | Exhibited CXCR4-specific tumor accumulation, with low uptake in background organs. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Mapping CSC-Mediated Ovarian Cancer Chemoresistance via CXCR4-PET to Guide Precision Cisplatin Re-Sensitization Therapy. Adv Sci (Weinh) 2026 Apr;13(19):e21279. PMID: 41632105
Increasing the activity output and optimization of automated radiosynthesis [68Ga]Ga-DOTATATE, [68Ga]Ga-Pentixafor, and [68Ga]Ga-FAPI-64 using two [68Ge]Ge/[68Ga]Ga iThemba generators in series. EJNMMI Radiopharm Chem 2026 Feb 17;11(1):16. PMID: 41701433
