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| Form | Solid |
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Compound Overview
Pentosan Polysulfate Sodium (W/W 43%) is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. It is also a potent, selective anti-HIV agent and is used for the treatment of interstitial cystitis[1][2][3]. It is supplied as a white to off-white solid (MW 4000-6000) at 43% purity.
Physical & Chemical Properties
| CAS Number | 140207-93-8 |
|---|---|
| Molecular Weight | 4000-6000 g/mol |
| Purity | 43% |
| Appearance | Solid |
| Color | White to off-white |
| Target | HIV-1 |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
Pentosan Polysulfate Sodium has been shown to inhibit HIV-1 activity in MT-4 cells, with an ED50 of 0.19 μg/mL. In HUT-78 cells, it inhibits HIV-1 antigen expression with an ED50 of 0.02 μg/mL, and HIV-1 antigen expression is fully inhibited at a concentration of 4.0 μg/mL[2]. Pentosan Polysulfate Sodium suppresses NF-κB, lessens the proinflammatory actions of TNFα, and reduces MCP-1 production stimulated by high glucose and advanced glycation end products (AGEs)[3].
In Vivo
Pentosan Polysulfate Sodium has been shown to reduce interstitial inflammation and glomerulosclerosis in 5/6 nephrectomized rats. Treatment with pentosan polysulfate preserves renal function, significantly lowers albuminuria, and markedly lessens the severity of renal lesions, including tubulointerstitial inflammation. In aging diabetic kidneys, Pentosan Polysulfate Sodium additionally curbs the upregulation of TNFα and proinflammatory genes[3].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Spontaneous generation of diverse recombinant prion strains: sulfated glycan cofactors facilitate strain emergence but do not determine specific strain properties. Acta Neuropathol Commun 2025 Dec 3;13(1):249. PMID: 41340161
Discovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation. Int J Mol Sci 2025 Feb 6;26(3):1381. PMID: 39941149
