| Field | Specification |
|---|---|
| Alternative names | Bleomycin PEP; Pepleomycin |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C61H88N18O21S2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Peplomycin, also known as Bleomycin PEP and Pepleomycin, is an analog of Bleomycin and an antitumor antibiotic with potent antitumor activity and relatively low pulmonary toxicity. It can induce various skin abnormalities and trigger apoptosis in SSCKN cells of oral squamous cell carcinoma, and it can also induce pulmonary fibrosis, making it applicable to research on tumors, pulmonary fibrosis and related conditions[1][2][3][4]. It has the molecular formula C61H88N18O21S2 and a molecular weight of 1473.59 g/mol.
Physical & Chemical Properties
| CAS Number | 68247-85-8 |
|---|---|
| Molecular Formula | C61H88N18O21S2 |
| Molecular Weight | 1473.59 g/mol |
| SMILES | O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@@](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(NCCCN[C@H](C4=CC=CC=C4)C)=O)=CS3)=CS2)=O)=O)=O)([H])[C@H](C5=CNC=N5)O[C@H]6[C@H]([C@H]([C@H](O)[C@H](CO)O6)O)O[C@]7([H])[C@H]([C@H]([C@H](O)[C@@H](CO)O7)OC(N)=O)O |
| Signaling Pathway | Apoptosis; Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Carter SK, et al. Peplomycin. Cancer Treat Rev. 1984 Dec;11(4):303-5.
[2]. Asano Y, et al. A case of peplomycin-induced scleroderma. Br J Dermatol. 2004 Jun;150(6):1213-4.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In human oral squamous carcinoma cell lines SSCKN and SCCTF, Peplomycin (0-100 μM; 30 h) inhibits the cells dose-dependently[3]. Peplomycin (1 μM and 10 μM; 30 h) causes nuclear fragmentation and chromatin condensation in a dose-dependent manner and induces apoptosis[3]. Peplomycin (5 mg/mL; 7 d) induces pulmonary fibrosis, distinguished from saline-injected rats (N-Fib), by differentiating fibroblasts into alpha-SMA-positive MF[4].
Cell Viability Assay[3]
| Cell Line | SSCKN and SCCTF cells |
|---|---|
| Concentration | 0, 1, 5, 10, 50, and 100 μM |
| Incubation Time | 30 hours |
| Result | Decreased SSCKN and SCCTF cells viability dose-dependently up to 50 μM, and resulted the viability of 38% and 30% that of the control group, respectively. |
In Vivo
Peplomycin (5 mg/kg; once daily) drives rat pulmonary fibroblasts toward myofibroblasts (MF); at the lung peripheries next to the pleura, advanced fibrosis is seen with a small number of alpha-smooth muscle actin (alpha-SMA)-positive MF, and ultrastructurally these cells carry abundant microfilaments and cellular organelles[4].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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