PF-06764427

SKU:BHB21900591
Overview
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PF-06764427 (CAS 1842371-08-7) is an agonist. Reported to act on mAChR1. Relevant to GPCR/G Protein and Neuronal Signaling research. Molecular formula C24H25N5O3, molecular weight 431.49 g/mol.
CAS Number 1842371-08-7
Molecular Weight 431.49 g/mol
Target mAChR1
Storage See Certificate of Analysis
Options selector
Catalog no. Size
HY-123852-50MG 50 mg
HY-123852-100MG 100 mg
HY-123852-250MG 250 mg
Available Options

Select the variant that best fits your experiment. Availability and lead time may vary by option.

  • Options: Size: 50 mg, 100 mg, 250 mg
  • Lead time: confirmed on inquiry for every option.
  • Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
  • Shipping: Room temperature in continental US; may vary elsewhere.
  • Upon receipt: store as stated on the Certificate of Analysis; contact us if you need the condition before ordering.
Field Specification
Target mAChR1
CAS no. 1842371-08-7
Applications
  • Functional Assay (In Vitro)
Molecular weight 431.49
Molecular formula C24H25N5O3
SMILES O=C(C1=CN(CC2=CC=C(C3=NN(C)C=C3)C=C2)C4=CC=CN=C41)N[C@@H]5[C@@H](O)COCC5
Storage Refer to Certificate of Analysis (CoA) for storage conditions
Shipping Room temperature in continental US; may vary elsewhere.
Catalog no. (Mfr.) HY-123852
Main SKU BHB21900591
Agonists

Compound Overview

PF-06764427 is a selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor and exhibits robust M1 agonist activity. It can be used in research on Alzheimer's disease and schizophrenia[1][2]. It has the molecular formula C24H25N5O3 and a molecular weight of 431.49 g/mol.

Physical & Chemical Properties

CAS Number 1842371-08-7
Molecular Formula C24H25N5O3
Molecular Weight 431.49 g/mol
SMILES O=C(C1=CN(CC2=CC=C(C3=NN(C)C=C3)C=C2)C4=CC=CN=C41)N[C@@H]5[C@@H](O)COCC5
Target mAChR1
Signaling Pathway GPCR/G Protein; Neuronal Signaling
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping Room temperature in continental US; may vary elsewhere.

Literature Cited

Sources cited in this description. Peer-reviewed publications that used this product are listed under References.

[1]. Davoren JE, et al. Design and optimization of selective azaindole amide M1 positive allosteric modulators. Bioorg Med Chem Lett. 2016 Jan 15;26(2):650-655.

[2]. Moran SP, et al. M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition. Neuropsychopharmacology. 2018 Jul;43(8):1763-1771.

Safety

For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.

Q.Why is there no price listed?
A.Every size of this product is quoted on inquiry. Send us the size you need and we will come back with price and lead time.
Q.Can this be used in humans or for diagnostics?
A.No. This product is supplied For Research Use Only. It is not for diagnostic or therapeutic procedures and not for human or veterinary use.

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