| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C19H20ClN5O4S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
PF-06807656 is a selective inhibitor of the renal outer medullary potassium channel (ROMK, or Kir1.1), with an IC50 of 61 nM against hROMK in patch-clamp assays. It shows high selectivity for inhibiting rat ROMK and is insensitive to N171D pore mutations, and it may be used in cardiovascular disease research[1]. It has the molecular formula C19H20ClN5O4S and a molecular weight of 449.91 g/mol.
Physical & Chemical Properties
| CAS Number | 2213468-04-1 |
|---|---|
| Molecular Formula | C19H20ClN5O4S |
| Molecular Weight | 449.91 g/mol |
| SMILES | O=C(NC(C1=NN(C)N=C1)C)C2=CC=C(OC)C(S(=O)(NC3=CC=C(Cl)C=C3)=O)=C2 |
| Signaling Pathway | Membrane Transporter/Ion Channel |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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