| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C19H16FN5O2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
PF-07059013 is an orally active, potent noncovalent modulator of sickled hemoglobin (HbS). It binds specifically to Hb with nanomolar affinity and partitions strongly into red blood cells (RBCs), and can be used for sickle cell disease (SCD) research[1][2]. The compound has the molecular formula C19H16FN5O2 and a molecular weight of 365.36 g/mol.
Physical & Chemical Properties
| CAS Number | 2435610-93-6 |
|---|---|
| Molecular Formula | C19H16FN5O2 |
| Molecular Weight | 365.36 g/mol |
| SMILES | NC1=NC(C=CC(F)=C2)=C2C=C1O[C@H](C3=C(N4C=CC=N4)C=CC(N3)=O)C |
| Signaling Pathway | Cardiovascular Disease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vivo
In Townes SCD mice, PF-07059013 (10-490 mg/kg by oral gavage, twice daily for 2 weeks) reduces sickling[1].
| Animal Model | Townes SCD mice (8-10 weeks old, male)[1] |
|---|---|
| Dosage | 10, 40, 200, and 490 mg/kg |
| Administration | Oral gavage, twice daily, for 2 weeks |
| Result | Showed a 37.8% (±9.0%) reduction in sickling at 200 mg/kg compared to vehicle treated mice. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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bioRxiv. 2025 May 13.
