| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Idronoxil |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Phenoxodiol (CAS 81267-65-4) is a research-grade small molecule supplied by TargetMol.
Alternative names: Idronoxil
Physical Properties
| CAS Number | 81267-65-4 |
|---|---|
| Molecular Formula | C15H12O3 |
| Molecular Weight | 240.25 g/mol |
| SMILES | OC=1C=C2C(C=C(CO2)C3=CC=C(O)C=C3)=CC1 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner. Phenoxodiol also inhibits DNA topoisomerase II.
Target(s): IAP, Caspase, Apoptosis, p53, Topoisomerase
Signaling pathway(s): Proteases/Proteasome, Apoptosis, DNA Damage/DNA Repair
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
The concentration of stock solution should be lower than the solubility provided on the official website. Within this range, the concentration of stock solution should be set based on that of working solution. For cell experiments, it is recommended to set the stock solution concentration at least 1000 times higher than that of working solution.
For normal mice, the concentration of DMSO should be kept below 10%. For nude mice, transgenic mice, or mice with weak tolerance, the concentration of DMSO should be kept below 2%. For inhibitors being used for the first time, it is recommended to perform a solvent-negative control experiment to confirm that the solvent has no nonspecific effects on the animals.
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