| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C28H29ClF2N10O4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
PI3Kα-IN-14 is a selective inhibitor of PI3Kα with an IC50 of 0.14 nM. It decreases mitochondrial membrane potential, leading to cell cycle arrest at G1 phase and apoptosis in U87-MG cells, and shows anti-proliferative activity against three tumor-derived cell lines: PC-3 (IC50 0.28 μM), HCT-116 (IC50 0.57 μM), and U87-MG (IC50 1.37 μM)[1]. It has the molecular formula C28H29ClF2N10O4 and a molecular weight of 643.04 g/mol.
Physical & Chemical Properties
| CAS Number | 3026856-46-9 |
|---|---|
| Molecular Formula | C28H29ClF2N10O4 |
| Molecular Weight | 643.04 g/mol |
| SMILES | O=C(N1CCN(C2=NC(N3C(C(F)F)=NC4=C(OC)C=CC=C34)=NC(N5CCOCC5)=N2)CC1)NNC(C6=CC=C(Cl)C=C6)=O |
| Target | PI3Kα, PI3Kγ, PI3Kδ, PI3Kβ |
| Signaling Pathway | PI3K/Akt/mTOR; Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
PI3Kα 0.14 nM (IC50) |
PI3Kγ 2.45 nM (IC50) |
PI3Kδ 5.69 nM (IC50) |
PI3Kβ 25.89 nM (IC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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