| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C45H39F2N5O12S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
PI3K-IN-41 is a photocaged PI3K inhibitor with anticancer properties (IC50 = 18.92 nM), suited to precisely controlled cancer therapeutics. Upon UV light irradiation, it exhibits potent PI3K inhibition and an enhanced antitumor effect[1]. It has the molecular formula C45H39F2N5O12S and a molecular weight of 911.88 g/mol.
Physical & Chemical Properties
| Molecular Formula | C45H39F2N5O12S |
|---|---|
| Molecular Weight | 911.88 g/mol |
| SMILES | COC1=CC(COC2=CC3=C(C=C(C(O3)=O)CN(S(C4=C(C=C(C=C4)F)F)(=O)=O)C5=C(N=CC(C6=CC7=C(N=CN=C7C(OC8CCOCC8)=C6)C)=C5)OC)C=C2)=C(C=C1OC)[N+]([O-])=O |
| Signaling Pathway | PI3K/Akt/mTOR |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50:18.92 nM (PI3K)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
PI3K-IN-41 (10 nM) lowers AKT phosphorylation in HGC-27 cells, and at 1-10 μM it inhibits colony formation by HGC-27 cells, following UV light irradiation for 5 min, 15 min, and 30 min[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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