| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C50H46F4N8O8S2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
PI3K-IN-47 is a bivalent PI3K inhibitor, with IC50 values of 0.44 nM, 7.18 nM, 13.92 nM and 22.83 nM against PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. It induces G1-phase cell cycle arrest, inhibits colony formation and cell migration, and inhibits tumor growth in HGC-27 xenograft mice[1]. It has the molecular formula C50H46F4N8O8S2 and a molecular weight of 1027.07 g/mol.
Physical & Chemical Properties
| Molecular Formula | C50H46F4N8O8S2 |
|---|---|
| Molecular Weight | 1027.07 g/mol |
| SMILES | CC1=C2C=C(C3=CN=C(OC)C(NS(C4=CC=C(F)C=C4F)(=O)=O)=C3)C=C(OCCCCCCCCOC5=CC(C6=CN=C(OC)C(NS(C7=CC=C(F)C=C7F)(=O)=O)=C6)=CC8=C(C)N=CN=C58)C2=NC=N1 |
| Signaling Pathway | PI3K/Akt/mTOR |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
Activity & Target
0.44 nM for PI3Kα, 7.18 nM, 13.92 nM, 22.83 nM for PI3Kβ, PI3Kγ, PI3Kδ[1]
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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