| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C17H14ClN3OS |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
PI3K/VEGFR2-IN-1 is a potent dual inhibitor of PI3K and VEGFR2, with IC50 values of 2.21 μM and 68 μM, respectively. It induces apoptosis and can be used in cancer research[1]. Its molecular formula is C17H14ClN3OS, with a molecular weight of 343.83 g/mol.
Physical & Chemical Properties
| CAS Number | 2851067-08-6 |
|---|---|
| Molecular Formula | C17H14ClN3OS |
| Molecular Weight | 343.83 g/mol |
| SMILES | S=C(N/N=C(C1=CC2=CC=CC=C2O1)\C)NC3=CC=C(Cl)C=C3 |
| Target | PI3K, VEGFR2 |
| Signaling Pathway | PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
PI3K 2.21 μM (IC50) |
VEGFR2 68 μM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In HePG2, MCF-7, Hela, and PC3 cells, PI3K/VEGFR2-IN-1 at 1.56-100 μM for 24 h inhibits cell proliferation in a dose-dependent manner[1]. In MCF-7 and Hela cells, PI3K/VEGFR2-IN-1 (10 mg/mL; 24 h) arrests the cell cycle at G1/S phase and induces apoptosis[1].
Cell Viability Assay[1]
| Cell Line | HePG2, MCF-7, Hela, and PC3 cells |
|---|---|
| Concentration | 1.56-100 μM |
| Incubation Time | 24 hours |
| Result | Had antitumor activity with IC50 values of 7.94, 9.73, 11.58, and 17.49 μM for Hela, HePG2, MCF-7 and PC3 cells, respectively. |
Cell Cycle Analysis[1]
| Cell Line | MCF-7 cells |
|---|---|
| Concentration | 10 mg/mL |
| Incubation Time | 24 hours |
| Result | Arrested cell cycle in G1/S phase at 24 h by 51.23%. |
Cell Cycle Analysis[1]
| Cell Line | MCF-7 and Hela cells |
|---|---|
| Concentration | 10 mg/mL |
| Incubation Time | 24 hours |
| Result | Enhanced late apoptotic induction with 14.11% at Hela cells. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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