| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H16F3NO4 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Picoxystrobin is a strobilurin fungicide that controls plant diseases by inhibiting mitochondrial respiration. It is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity[1][2]. It is supplied as a light yellow to brown solid (C18H16F3NO4, MW 367.32) at 99.76% purity.
Physical & Chemical Properties
| CAS Number | 117428-22-5 |
|---|---|
| Molecular Formula | C18H16F3NO4 |
| Molecular Weight | 367.32 g/mol |
| Purity | 99.76% |
| Appearance | Solid |
| Color | Light yellow to brown |
| SMILES | O=C(OC)/C(C(C=CC=C1)=C1COC2=CC=CC(C(F)(F)F)=N2)=C/OC |
| Signaling Pathway | NF-κB; Metabolic Enzyme/Protease; Immunology/Inflammation; Anti-infection |
| Solubility | In Vitro: DMSO: 100 mg/mL (272.24 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (272.24 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% saline |
|---|---|
| Result | ≥ 2.5 mg/mL (6.81 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 400 μL PEG300; then 50 μL Tween-80; then 450 μL saline to bring the volume to 1 mL. Saline: dissolve 0.9 g sodium chloride in ddH2O and make up to 100 mL. |
Protocol 2
| Composition | 10% DMSO + 90% Corn Oil |
|---|---|
| Result | ≥ 2.5 mg/mL (6.81 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). Use with caution if continuous dosing will exceed two weeks. For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL corn oil. |
Data provided by the manufacturer.
In Vivo
In zebrafish embryos, Picoxystrobin (0-400 μg/L; waterborne exposure; 24-144 h) alters mortality, hatching rate and teratogenic rate in a dose- and time-dependent manner, with a 144-h LC50 of 213.8 μg/L[1]. Zebrafish embryos exposed to Picoxystrobin (60-105 μg/L; waterborne exposure; 96 h) show developmental toxicity, oxidative stress and immunotoxicity[2].
| Animal Model | Wild type AB-strain zebrafish embryos[2] |
|---|---|
| Dosage | 60, 69, 79, 91, 105 μg/L |
| Administration | Embryos at 2 hpf were exposed to picoxystrobin solutions in 24-well culture plates (1 embryo per well), and the exposure solution was renewed every 24 h for 96 h |
| Result | Showed high toxicity to zebrafish embryos with a 96-h LC50 of 86 μg/L, causing decreased heartbeat, hatching inhibition, growth regression, morphological deformities, increased ROS and MDA contents, decreased SOD activity and GSH content, induced CAT activity, and altered expressions of genes related to antioxidant system and innate immune system. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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