| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C11H9NO3S |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Pim-1/2 kinase inhibitor 1 is an orally active inhibitor of Pim-1/2 kinase. It blocks the ability of Pim kinases to phosphorylate peptides and inhibits Pim protein kinase-directed phosphorylation of 4E-BP1 and p27 Kip1, and it can be used in the study of cancer, especially prostate cancer[1]. It is supplied as a light yellow to yellow solid (C11H9NO3S, MW 235.26) at 99.78% purity.
Physical & Chemical Properties
| CAS Number | 6320-51-0 |
|---|---|
| Molecular Formula | C11H9NO3S |
| Molecular Weight | 235.26 g/mol |
| Purity | 99.78% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| SMILES | O=C(NC1=O)SC1=CC2=CC=C(OC)C=C2 |
| Signaling Pathway | JAK/STAT Signaling |
| Solubility | In Vitro: DMSO: 250 mg/mL (1062.65 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Charles D. Smith, et al. Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer. Patent US20110263664A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 250 mg/mL (1062.65 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 90% Corn Oil |
|---|---|
| Result | ≥ 2.08 mg/mL (8.84 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.08 mg/mL (saturation not determined). Use with caution if continuous dosing will exceed two weeks. For 1 mL of working solution: add 100 μL DMSO stock (20.8 mg/mL) to 900 μL corn oil. |
Data provided by the manufacturer.
In Vitro
Cytotoxicity toward PC3 cells is shown by Pim-1/2 kinase inhibitor 1 (varying concentrations; 48 h).
Cell Cytotoxicity Assay[1]
| Cell Line | PC3 cells |
|---|---|
| Concentration | varying concentrations |
| Incubation Time | 48 h |
| Result | Inhibited PC3 cells with an IC50 of 11 μM. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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