| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone |
| Cas No. | |
| Form | Cream Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 25 mg/ml DMSO |
| Source | Synthetic |
| Storage |
Piperlongumine is a naturally derived compound known for its selective cytotoxicity against cancer cells by disrupting their oxidative stress response. In neuroscience, its relevance lies in its ability to modulate reactive oxygen species (ROS), which are implicated in neurodegenerative processes. By inhibiting platelet aggregation induced by specific stimuli and sparing normal cells, Piperlongumine offers a potential therapeutic avenue for neuroinflammation and oxidative stress-related neuronal damage. Its antioxidant modulation may contribute to neuroprotection in disorders such as Alzheimer's and Parkinson's disease.
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302
Piperlongumine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-156)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Raj L., et al. (2011) Nature. 475(7355): 231.
