| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,Ndimethylacetamide . HCl |
| Cas No. | |
| Form | White to yellow solid. |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (30 mg/ml) or water (20 mg/ml) |
| Source | Synthetic |
| Storage |
PJ-34 is a potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell death pathways. In neuroscience, PJ-34 is used to study neuroprotection in models of ischemia, traumatic brain injury, and neurodegeneration. PARP overactivation leads to energy depletion and neuronal death, and PJ-34 mitigates this by preserving cellular NAD⁺ levels. Its anti-inflammatory and anti-apoptotic effects make it a valuable compound for exploring therapeutic strategies aimed at reducing neuronal damage and promoting recovery in neurodegenerative conditions.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
PJ-34 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-366)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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