| Field | Specification |
|---|---|
| Alternative names | ACHN 490 |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C25H48N6O10 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Plazomicin, also known as ACHN 490, is a semi-synthetic aminoglycoside Antibiotic. It serves as a substrate for aminoglycoside acetyltransferase and aminoglycoside phosphotransferase, yet it is not modified by various common aminoglycoside-modifying enzymes, and it selectively inhibits MATE2-K. It is active against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales[1][2]. It has the molecular formula C25H48N6O10 and a molecular weight of 592.68 g/mol.
Physical & Chemical Properties
| CAS Number | 1154757-24-0 |
|---|---|
| Molecular Formula | C25H48N6O10 |
| Molecular Weight | 592.68 g/mol |
| SMILES | O[C@H]([C@H]([C@@](C)(O)CO1)NC)[C@@]1([H])O[C@H]2[C@@H](C[C@H](N)[C@@H](O[C@@]3([H])OC(CNCCO)=CC[C@H]3N)[C@@H]2O)NC([C@@H](O)CCN)=O |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Against Klebsiella, Escherichia, Enterobacter, Serratia, and Citrobacter species, Plazomicin shows MIC50/90 = 0.25-0.5 μg/mL/0.5-1 μg/mL[1]. Plazomicin selectively inhibits MATE2-K, and to a lesser degree MATE1 and OCT2, which are important transporters in tubular secretion[1]. Plazomicin (18 h) keeps its antibacterial activity against most E. coli BW25113 and E. coli BW25113 ΔbamB ΔtolC strains that express aminoglycoside modifying enzymes[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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A dual-function chromogenic and fluorogenic benzofurazan probe for plazomicin and its innovative utility for development of two microwell assays with high throughput for analysis of drug substance and pharmaceutical formulations. RSC Adv 2024 Aug 27;14(37):27215-27226. PMID: 39193289
