| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Phorbol 12-myristate 13-acetate |
| Cas No. | |
| Form | Colorless amorphous film or foam |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (25 mg/ml), 100% ethanol (25 mg/ml), acetone, ether or dimethyl formamide; almost insoluble in aqueous buffers |
| Source | Synthetic |
| Storage |
PMA is a potent phorbol ester widely used as a reversible activator of protein kinase C (PKC). In neuroscience, PMA serves as a critical tool for studying synaptic plasticity, signal transduction, and neuroinflammation. By mimicking diacylglycerol, PMA activates PKC isoforms, influencing neuronal gene expression, neurotransmitter release, and long-term potentiation. Its ability to modulate neuroinflammatory pathways and glial activation makes it relevant in models of neurodegenerative diseases such as Alzheimer's and Parkinson's. PMA is also used to investigate tumor-promoting mechanisms in neural tissues, offering insights into brain cancer biology.
Classification: Skin irritation (Category 2), H315
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H315 Causes skin irritation.
Precautionary statements:
- P264 Wash skin thoroughly after handling.
- P280 Wear protective gloves.
- P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
- P321 Specific treatment (see supplemental first aid instructions on this label).
- P332 + P313 If skin irritation occurs: Get medical advice/ attention.
- P362 Take off contaminated clothing and wash before reuse.
PMA (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-508)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Castagna M., et al. (1982) J. Biol. Chem. 257(13): 7847–7851.
