| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea.
- CAS number: 501925-31-1
- Molecular formula: C13H14ClN3O4.
- Purity: >98% (HPLC)
- Concentration: 0.3-10 µM.
- Form: Lyophilized powder.
- Solubility: Soluble to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: α7 nAChR
- Source: Synthetic
- Activity: PNU-120596 is a potent and selective type-II positive allosteric modulator of α7 nicotinic acetylcholine receptors, shown to potentiate α7 currents in X. Laevis oocytes and in SH-EP1 cells with EC50 values of 1.6 µM and 216 nM, respectively1-2. Neuroprotective in vivo3.
Scientific background
PNU-120596 is as a potent and selective positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs). It potentiates nAChR α7 currents in Xenopus oocytes and in SH-EP1 cells with EC50 values of 1.6 µM and 216 nM, respectively1-2. The compound displays neuroprotective characteristics in vivo and has the ability to increase the potency and maximal efficacy of agonists and to prolong the duration of the agonist-evoked macroscopic currents1,2.nAChRs receptors are responsible for mediating the effects of the neurotransmitter acetylcholine (ACh). They play critical roles in the central and peripheral nervous system where they regulate neurotransmitter release, cell excitability, neuronal integration. They are involved in functions such as sleep and arousal patterns, fatigue, hunger, anxiety, and pain processing2,3,4.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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