| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Purity | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Polatuzumab vedotin is an antibody-drug conjugate that targets CD79b, containing a humanized anti-CD79b IgG1 monoclonal antibody linked to monomethyl auristatin E (MMAE), a potent microtubule inhibitor. Its antibody portion is Polatuzumab, and its drug-linker conjugate is VcMMAE; it has potential application in research on large B-cell lymphomas (LBCL)[1]. It is supplied as a white to off-white solid with an average molecular weight of 150000 at 99.29% purity.
Physical & Chemical Properties
| CAS Number | 1313206-42-6 |
|---|---|
| Molecular Weight | 150000 g/mol (average) |
| Purity | 99.29% |
| Appearance | Solid |
| Color | White to off-white |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related; Immunology/Inflammation |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Shipping with dry ice. |
| Preparation Instructions | The product can be reconstituted/diluted with sterile PBS or saline. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vivo
In a mouse tumour xenograft model of human diffuse large B-cell lymphoma WSU-DLCL2, Polatuzumab vedotin (0.3, 1, 3, 6, 12 mg/kg; i.v.; once) exhibits anti-tumor activity[2].
| Animal Model | SCID mice (human diffuse large B-cell lymphoma WSU-DLCL2)[2] |
|---|---|
| Dosage | 0.3, 1, 3, 6, 12 mg/kg |
| Administration | I.v.; once |
| Result | Showed dose-dependent tumour growth inhibition. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
Direct Visualization and Quantitative Modeling of Mass Transport Limitation in Biomolecular Kinetics via Imaging-Based Meta-SPR. Anal Chem 2026 Mar 24;98(11):8382-8393. PMID: 41814478
