| Field | Specification |
|---|---|
| Target | |
| Applications | |
| Purity | |
| Form | Solid |
| Storage | |
| Shipping | |
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Compound Overview
Poly (I:C):Kanamycin (1:1) sodium is an isometric complex combining Poly (I:C) and Kanamycin. The Poly(I:C) sodium component is a synthetic double-stranded RNA analog that agonizes TLR3 and the retinoic acid-inducible gene I receptor (RIG-I and MDA5); it can act as a vaccine adjuvant that boosts innate and adaptive immune responses and triggers apoptosis in cancer cells[1][2]. The Kanamycin component is an orally active antibacterial agent effective against both Gram-negative and Gram-positive bacteria, working by binding the 70S ribosomal subunit to block translocation and cause miscoding; it is notably active against Mycobacterium tuberculosis, including drug-resistant strains, and against Klebsiella pneumoniae, and can be used in research on tuberculosis and pneumonia[3]. The complex is supplied as a white to off-white solid at 99.0% purity.
Physical & Chemical Properties
| Purity | 99.0% |
|---|---|
| Appearance | Solid |
| Color | White to off-white |
| Target | MDA5, RIG-I, TLR3 |
| Signaling Pathway | Immunology/Inflammation; Apoptosis |
| Solubility | In Vitro: H2O: 50 mg/mL (Requires sonication) DMSO: < 1 mg/mL (insoluble or slightly soluble) |
| Storage | -20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 50 mg/mL | requires sonication |
| DMSO | < 1 mg/mL | insoluble or slightly soluble |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
In WM793, WM278, WM239A, WM9 and 1205Lu cells, Poly (I:C) sodium (20 ng/mL; 24 hours) strongly lowers viability from 100% in controls to 20%–50% within 24 hours[1]. In 1205Lu cells, Poly (I:C) sodium (200 ng/mL; 24 hours) induces apoptosis[1]. Poly (I:C) sodium (3 ng/mL; 24 hours; 1205Lu cells) triggers IFN-β expression in melanoma cells. Silencing RIG-I and MDA-5 showed that Poly (I:C) sodium-induced IFN-β expression required RIG-I and MDA-5, respectively, and that IPS-1 was also required[1]. Active subunits of caspase-9 and caspase-8 are revealed in melanoma cells by Poly (I:C) sodium (5 ng/mL; 24 hours; 1205Lu cells)[1]. Kanamycin (0.1-100 μg/mL; 2 weeks) shows good antibacterial activity against various mycobacterial strains in vitro (MIC=1-5 μg/mL)[3].
In Vivo
In NOD/SCID immunodeficient mice injected with 1205Lu cells, Poly (I:C) sodium treatment inhibits tumor growth, and human DNA levels are 50% lower in treated mice[1]. In mice, the growth of bovine tubercle bacilli in lung and spleen is inhibited by Kanamycin (2, 4 mg/kg; s.c.; 6 times a week for 3 weeks, once daily)[3]. Kanamycin (1.25, 5 mg/kg; s.c.; single dose at 3 h after infection) inhibits multiplication of K. pneumonia DT-S in the lung, trachea, and blood of mice, in proportion to the dose given, and also increases mouse survival.
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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