| Field | Specification |
|---|---|
| Target | |
| Alternative names | LY2140023 hydrochloride |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C12H19ClN2O7S2 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Pomaglumetad methionil hydrochloride, also known as LY2140023 hydrochloride, is an orally active methionine prodrug of LY404039, a selective mGlu2/3 receptor agonist. It has potential for use in schizophrenia research[1][2]. It is supplied as an off-white to light yellow solid (C12H19ClN2O7S2, MW 402.87) at 98.0% purity.
Physical & Chemical Properties
| CAS Number | 635318-26-2 |
|---|---|
| Molecular Formula | C12H19ClN2O7S2 |
| Molecular Weight | 402.87 g/mol |
| Purity | 98.0% |
| Appearance | Solid |
| Color | Off-white to light yellow |
| SMILES | CSCC[C@H](N)C(N[C@]([C@@]1([H])[C@](S2(=O)=O)([H])[C@@H]1C(O)=O)(C2)C(O)=O)=O.[H]Cl |
| Target | mGluR2, mGluR3 |
| Signaling Pathway | GPCR/G Protein; Neuronal Signaling |
| Solubility | In Vitro: DMSO: 25 mg/mL (62.05 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 25 mg/mL (62.05 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); stored under nitrogen; avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% saline |
|---|---|
| Result | ≥ 2.5 mg/mL (6.21 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 400 μL PEG300; then 50 μL Tween-80; then 450 μL saline to bring the volume to 1 mL. Saline: dissolve 0.9 g sodium chloride in ddH2O and make up to 100 mL. |
Protocol 2
| Composition | 10% DMSO + 90% (20% SBE-β-CD in saline) |
|---|---|
| Result | ≥ 2.5 mg/mL (6.21 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL 20% SBE-β-CD in saline. 20% SBE-β-CD in saline: dissolve 2 g SBE-β-CD powder in 10 mL saline until clear (4°C, store up to one week). |
Protocol 3
| Composition | 10% DMSO + 90% Corn Oil |
|---|---|
| Result | ≥ 2.5 mg/mL (6.21 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). Use with caution if continuous dosing will exceed two weeks. For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL corn oil. |
Data provided by the manufacturer.
In Vitro
Pomaglumetad methionil (LY2140023) acts as a high-affinity substrate of peptide transporter 1 (PEPT1), with a Km of ~30 μM[2]. LY2140023 shows activity against [14C]Gly-Sar, with an IC50 of 0.018 mM[2].
In Vivo
Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) raises dopamine metabolite levels, namely dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in a dose-dependent manner[1].
| Animal Model | Male Fischer rats (approximately 250 g)[1] |
|---|---|
| Dosage | 3 mg/kg, 10 mg/kg, and 300 mg/kg |
| Administration | Orally; once daily for 7 days |
| Result | Dose-dependent increased the levels of the dopamine metabolites DOPAC and HVA. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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