| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C52H66N2O20P2 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Pomstafib-2 is a potent, selective STAT5b inhibitor that decreases pSTAT5b expression and induces apoptosis[1][2]. It is supplied as a white to light yellow solid (C52H66N2O20P2, MW 1101.03) at 99.37% purity.
Physical & Chemical Properties
| CAS Number | 2332841-83-3 |
|---|---|
| Molecular Formula | C52H66N2O20P2 |
| Molecular Weight | 1101.03 g/mol |
| Purity | 99.37% |
| Appearance | Solid |
| Color | White to light yellow |
| SMILES | O=C(NCC1=CC=C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)=C1)COC2=CC=C(C(NC3=CC=C(OC4=CC=CC=C4)C=C3)=O)C=C2 |
| Signaling Pathway | Stem Cell/Wnt; JAK/STAT Signaling; Apoptosis |
| Solubility | In Vitro: DMSO: 175 mg/mL (158.94 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 175 mg/mL (158.94 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
In STAT5b-GFP-transfected K562 cells, Pomstafib-2 (0-10 μM; 4 h) lowers pSTAT5b expression in a dose-dependent manner[1]. In STAT5-dependent K562 cells, apoptosis is induced dose-dependently by Pomstafib-2 (0, 10, 20, 40, 60, 80 μM; 48 h)[1].
Western Blot Analysis[1]
| Cell Line | K562 leukaemia cells |
|---|---|
| Concentration | 0, 0.3, 1, 3, 10 μM |
| Incubation Time | 4 h |
| Result | Decreased the expression of pSTAT5b in a dose-dependent manner. |
Apoptosis Analysis[1]
| Cell Line | K562, MDA-MB-231 cells |
|---|---|
| Concentration | 0, 10, 20, 40, 60, 80 μM |
| Incubation Time | 48 h |
| Result | Induced apoptosis in a dose-dependent manner in K562 cells, does not increased the apoptotic rate of STAT5-independent MDA-MB-231 cells. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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